Microbiome Profiling of Subgingival Plaque in Patients with Aggressive Periodontitis Using Next-Generation Sequencing Techniques
Keywords:
Aggressive periodontitis, microbiome profiling, next-generation sequencing, subgingival plaque, 16S rRNA sequencing, periodontal pathogensAbstract
Aggressive periodontitis is a rapidly progressing periodontal disease associated with distinct subgingival microbial communities. Next-generation sequencing (NGS) technologies have revolutionized microbiome profiling, enabling a comprehensive analysis of microbial diversity in subgingival plaque. This study explores the bacterial composition of subgingival samples from patients diagnosed with aggressive periodontitis, using 16S rRNA gene sequencing. Our findings reveal significant alterations in microbial diversity, with increased prevalence of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and other pathobionts. The study also emphasizes the utility of NGS in identifying biomarkers for early diagnosis and personalized periodontal care.
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