Synthetic Biology Approaches for Programmable Immunomodulation in the Treatment of Drug-Resistant Infectious Diseases
Keywords:
Synthetic biology, immunomodulation, drug resistance, genetic circuits, engineered immunity, infectious diseases, CRISPR, cell-based therapy, microbial therapeuticsAbstract
The rise of drug-resistant infectious diseases has escalated into a critical global health emergency, prompting the urgent need for novel therapeutic paradigms. Synthetic biology offers transformative strategies by enabling programmable immunomodulation—precise manipulation of host immune responses using engineered biological systems. This paper explores recent advancements in synthetic biology from a perspective, focusing on programmable genetic circuits, engineered immune cells, and synthetic microbial therapeutics tailored to combat multi-drug-resistant pathogens. We review literature up to 2024, discuss emerging clinical and preclinical frameworks, and present a forward-looking view of how synthetic biology can be integrated into precision immunotherapy for infectious diseases. Challenges such as delivery efficiency, biosafety, and regulatory hurdles are also examined.
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Copyright (c) -1 G. Deepak Aryan (Author)
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