Evaluating the Effectiveness of Enhanced Infection Control Protocols on Reducing Hospital-Acquired Infections in Critical Care Units
Keywords:
Hospital-acquired infections, infection control protocols, critical care, patient safety, evidence-based practiceAbstract
Hospital-acquired infections (HAIs) in critical care units remain a pervasive threat to patient safety despite advances in medical technology and antimicrobial therapies. This study evaluates the effectiveness of enhanced infection control protocols (EICPs) implemented in 2024 across three tertiary hospitals. A quasi-experimental pre-post design compared infection rates before and after protocol adoption. Results indicate a statistically significant reduction in HAIs, particularly ventilator-associated pneumonia and catheter-related bloodstream infections. These findings underscore the critical role of multidisciplinary infection control measures and continuous staff training in mitigating nosocomial infections.
References
[1] Allegranzi, Benedetta, and Didier Pittet. "Role of Hand Hygiene in Healthcare-Associated Infection Prevention." Journal of Hospital Infection, vol. 73, no. 4, 2009, pp. 305–315.
[2] Erasmus, Vicki, et al. "Systematic Review of Studies on Compliance with Hand Hygiene Guidelines in Hospital Care." Infection Control & Hospital Epidemiology, vol. 31, no. 3, 2010, pp. 283–294.
[3] Magill, Shelley S., et al. "Multistate Point-Prevalence Survey of Health Care–Associated Infections." The New England Journal of Medicine, vol. 370, no. 13, 2014, pp. 1198–1208.
[4] Pronovost, Peter, et al. "An Intervention to Decrease Catheter-Related Bloodstream Infections in the ICU." The New England Journal of Medicine, vol. 355, no. 26, 2006, pp. 2725–2732.
[5] Siegel, Jane D., et al. "2007 Guideline for Isolation Precautions: Preventing Transmission of Infectious Agents in Healthcare Settings." Centers for Disease Control and Prevention, 2007.
[6] Zingg, Walter, and Didier Pittet. "Peripheral Venous Catheters: An Under-Evaluated Problem." International Journal of Antimicrobial Agents, vol. 34, suppl. 4, 2009, pp. S38–S42.
[7] Pittet, Didier. "Improving Adherence to Hand Hygiene Practice: A Multidisciplinary Approach." Emerging Infectious Diseases, vol. 7, no. 2, 2001, pp. 234–240.
[8] World Health Organization. WHO Guidelines on Hand Hygiene in Health Care: First Global Patient Safety Challenge Clean Care Is Safer Care. World Health Organization, 2009.
[9] Burke, John P. "Infection Control: A Problem for Patient Safety." The New England Journal of Medicine, vol. 348, no. 7, 2003, pp. 651–656.
[10] Harbarth, Stephan, et al. "Evaluating the Probability of Previously Unknown Carriage of MRSA at Hospital Admission." American Journal of Medicine, vol. 125, no. 6, 2012, pp. 555–561.
[11] Klevens, R. Monina, et al. "Estimating Health Care-Associated Infections and Deaths in U.S. Hospitals, 2002." Public Health Reports, vol. 122, no. 2, 2007, pp. 160–166.
[12] Stone, Patricia W., et al. "Economic Burden of Healthcare-Associated Infections: An American Perspective." Expert Review of Pharmacoeconomics & Outcomes Research, vol. 5, no. 4, 2005, pp. 417–432.
[13] Allegranzi, B., Pittet, D., & World Health Organization. (2011). Role of hand hygiene in healthcare-associated infection prevention. Journal of Hospital Infection, 77(4), 305–315. https://doi.org/10.1016/j.jhin.2011.05.004
[14] Krein, S. L., Kowalski, C. P., Hofer, T. P., & Saint, S. (2019). Preventing device-associated infections in US hospitals: national surveys from 2005 to 2016. JAMA Internal Medicine, 179(6), 790–793. https://doi.org/10.1001/jamainternmed.2019.0082
[15] Magill, S. S., O’Leary, E., Janelle, S. J., et al. (2018). Changes in prevalence of healthcare-associated infections in U.S. hospitals. New England Journal of Medicine, 379(18), 1732–1744. https://doi.org/10.1056/NEJMoa1801550
[16] Weiner-Lastinger, L. M., Abner, S., Edwards, J. R., et al. (2020). Antimicrobial-resistant pathogens associated with adult healthcare-associated infections: summary of data reported to the National Healthcare Safety Network, 2015–2017. Infection Control & Hospital Epidemiology, 41(1), 1–18. https://doi.org/10.1017/ice.2019.296
[17] World Health Organization. (2017). Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics. https://www.who.int/publications/i/item/WHO-EMP-IAU-2017.12
[18] Huang, S. S., Septimus, E., Kleinman, K., et al. (2013). Targeted versus universal decolonization to prevent ICU infection. New England Journal of Medicine, 368(24), 2255–2265. https://doi.org/10.1056/NEJMoa1207290
[19] Marra, A. R., Edmond, M. B., & Wenzel, R. P. (2011). Controversies in infection prevention: can we use historical controls? Clinical Infectious Diseases, 53(6), 720–722. https://doi.org/10.1093/cid/cir492
[20] Boyce, J. M., & Pittet, D. (2002). Guideline for hand hygiene in health-care settings. Morbidity and Mortality Weekly Report, 51(RR-16), 1–44. https://www.cdc.gov/mmwr/PDF/rr/rr5116.pdf
[21] Boyce, J. M. (2017). Electronic monitoring in combination with direct observation as a means to significantly improve hand hygiene compliance. American Journal of Infection Control, 45(5), 528–535. https://doi.org/10.1016/j.ajic.2016.12.018
[22] Pronovost, P., Needham, D., Berenholtz, S., et al. (2006). An intervention to decrease catheter-related bloodstream infections in the ICU. New England Journal of Medicine, 355(26), 2725–2732. https://doi.org/10.1056/NEJMoa061115
[23] Zingg, W., Holmes, A., Dettenkofer, M., et al. (2015). Hospital organisation, management, and structure for prevention of health-care-associated infection: a systematic review and expert consensus. The Lancet Infectious Diseases, 15(2), 212–224. https://doi.org/10.1016/S1473-3099(14)70854-0
[24] Huang, S. S., Septimus, E., Kleinman, K., et al. (2013). Targeted versus universal decolonization to prevent ICU infection. New England Journal of Medicine, 368(24), 2255–2265. https://doi.org/10.1056/NEJMoa1207290
[25] Pronovost, P., Needham, D., Berenholtz, S., et al. (2006). An intervention to decrease catheter-related bloodstream infections in the ICU. New England Journal of Medicine, 355(26), 2725–2732. https://doi.org/10.1056/NEJMoa061115
[26] Erasmus, V., Daha, T. J., Brug, H., et al. (2010). Infect Control Hosp Epidemiol, 31(3), 283–294. https://doi.org/10.1086/650451